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Overview

Upon detection of beta-amyloid plaques (by receptor protein binding or by miRNA sensing) a transcription factor is cleaved from the receptor protein (LilrB2 or PirB) to then promote expression of a miRNA as well as BACE2. This miRNA, in turn, down-regulates BACE1. 

TO DO

Parts Diagram

Lab Notebook


                            

 

Experiments

 

Experiment

Demonstrate effectiveness of miRNA in down-regulating BACE1

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Demonstrate inducible upregulation of BACE2-YFP

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Purchases

 

ItemLink
BACE2http://dnasu.org/DNASU/GetCloneDetail.do?cloneid=76140
BACE1http://dnasu.org/DNASU/GetCloneDetail.do?cloneid=78236
Bace2 activity assayhttps://www.anaspec.com/products/product.asp?id=57836
Bace1 activity assayhttp://www.anaspec.com/products/product.asp?id=57888

 

Relevant Papers

 

 

 

 

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