• Created by Unknown User (lylaatta@mit.edu), last modified by Unknown User (jamesa@mit.edu) on Jul 17, 2014 11:31
ARTICLECLAIMED

BRIEF SUMMARY

SUBSEQUENT QUESTIONS/ FURTHER RESEARCH

http://www.nature.com/gt/journal/v20/n8/full/gt2012100a.htmlLA, KB, SS

Using engineered embryonic stem cell derived microglia as a delivery vehicle in ex vivo gene therapy:

They used microglia transduced with GFP then NT-3 and administered them intra-venously into mice that were induced with a demyelinating disease (experimental autoimmune encaphalomyelitis).

They found that the microglia were able to enter the spinal cord but not the brain and that they migrated to inflammatory regions which could be useful in Alzheimer's Disease due to the inflammation associated with plaques.

  • Microneurosurgery
  • culturing microglia
  • human trials? brain
  • Similar experiments, but in context of Alzheimer's disease
  • potential cross talk with our system
http://neuralsci.org/our-research/alzheimers-program   

Trojan Horse Liposome:

JADescriptions of how "Trojan Horse Liposomes" are used to deliver expression vectors across the blood-brain barrier with cell type specificity. 
    
    

 

 

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