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Overview

Upon detection of beta-amyloid plaques (by receptor protein binding or by miRNA sensing) a transcription factor is cleaved from the receptor protein (LilrB2 or PirB) to then promote expression of a miRNA as well as BACE2. This miRNA, in turn, down-regulates BACE1. 

Project Plan

TO DO

 

 

Experiments

 

ExperimentExpected ResultsControlsProtocolsPartsCompleted?
Assay down-regulation of BACE1 by U6/miRNA     
   
   
   
Assay transcription factor's effectiveness in promoting expression of miRNA/BACE2     
     
     
     
      
     
     
     
      
     
     
     

 

Purchases

ItemLinkPurchased?
BACE2http://dnasu.org/DNASU/GetCloneDetail.do?cloneid=41166 
   
   

 

Appendix

Relevant Papers

data sets

 

https://www.addgene.org/26736/ (mouse BACE1 for $65)

http://dnasu.org/DNASU/GetCloneDetail.do?cloneid=78236 (human BACE1; pricing given only to registered customers)

 

 

 

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